Haunting the HOXA Locus: Two Faces of lncRNA Regulation.
basic_science · Level V
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- Record sourced from PubMed, PMID 25957895.
- Also identified by DOI 10.1016/j.stem.2015.04.010.
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Abstract
Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.
Medical subject headings
- Embryonic Stem Cells
- Homeodomain Proteins
- RNA, Long Noncoding