Pushing and pulling on adult neural stem cells.

Ibrayeva, Albina; Bonaguidi, Michael A · Cell Stem Cell · 2015

editorial · Level V

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Abstract

How plastic is adult neurogenesis? In this issue of Cell Stem Cell, Sierra et al. (2015) use epilepsy models to probe how hippocampal neural stem cells (NSCs) respond to graded pathological conditions. They uncover changes in cell fate potential upon NSC activation, but it comes at a cost.

Medical subject headings