Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25957897.
- Also identified by DOI 10.1016/j.stem.2015.04.018 and PMC identifier 5124373.
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Abstract
3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.
Medical subject headings
- Endothelial Cells
- Kidney
- Mesenchymal Stem Cells
- Pancreas
- Pluripotent Stem Cells
- Stem Cells