Converting a Problem into an Opportunity: mtDNA Heteroplasmy Shift.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25957899.
- Also identified by DOI 10.1016/j.stem.2015.04.012.
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Abstract
The transmission of mitochondrial DNA (mtDNA) disease from a mother with a heteroplasmic mtDNA mutation to her children is unpredictable. In a recent issue of Cell, Reddy et al. (2015) present the potential for mitochondrial-targeted nucleases to remove mutated mtDNA through the induction of heteroplasmy shift in oocytes and zygotes.
Medical subject headings
- Gene Targeting
- Mitochondrial Diseases