Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25957900.
- Also identified by DOI 10.1016/j.stem.2015.04.009.
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Abstract
Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets during human development.
Medical subject headings
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methylation
- Embryonic Stem Cells