Soluble Glycoprotein Is Not Required for Ebola Virus Virulence in Guinea Pigs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25957965.
- Also identified by DOI 10.1093/infdis/jiv111 and PMC identifier 4564536.
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Abstract
Ebola virus (EBOV) uses transcriptional editing to express several glycoproteins (GPs), including secreted soluble GP (sGP) and structural GP1,2, from a single gene. Recombinant viruses predominantly expressing GP1,2 are known to rapidly mutate and acquire an editing site predominantly expressing sGP in vivo, suggesting an important role of this protein during infection. Therefore, we generated a recombinant virus that is no longer able to express sGP and assessed its virulence in the EBOV guinea pig model. Surprisingly, although this virus remained genetically stable, it did not show any significant attenuation in vivo, showing that sGP is not required for virulence in this model.
Medical subject headings
- Ebolavirus
- Glycoproteins
- Hemorrhagic Fever, Ebola
- Viral Proteins
- Virulence