Embryonic stem cells as sources of donor-independent platelets.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25961451.
- Also identified by DOI 10.1172/JCI82348 and PMC identifier 4497771.
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Abstract
The creation of a donor-independent source of platelets has been challenging; however, recent advances show growing promise for alternative platelet sources. Pluripotent stem cells have the capacity to differentiate into mature megakaryocytes with the ability to produce functional platelets. In this issue of JCI, Noh et al. provide a proof-of-principle demonstration that embryonic stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. This study emphasizes the importance of precise regulation of gene expression for regenerative medicine applications.
Medical subject headings
- Anti-Bacterial Agents
- Cell Differentiation
- Doxycycline
- Embryonic Stem Cells
- GATA1 Transcription Factor
- Megakaryocyte-Erythroid Progenitor Cells
- Thrombopoietin