Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25962336.
- Also identified by DOI 10.1002/adma.201500417 and PMC identifier 4633528.
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Abstract
Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.
Medical subject headings
- Drug Delivery Systems
- Enzymes
- Nanostructures
- Proteins