The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25981053.
- Also identified by DOI 10.1016/j.radonc.2015.04.023.
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Abstract
We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.
Medical subject headings
- Carbon Dioxide
- Fluorodeoxyglucose F18
- Hypoxia
- Oxygen
- Radiopharmaceuticals