Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25981929.
- Also identified by DOI 10.1002/adma.201500900.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors. Moreover, this tendency can be altered by varying the geometry and composition of the micropatterns.
Medical subject headings
- Cell Movement
- Focal Adhesions
- Integrin alpha5beta1
- Integrin alphaVbeta3