First Direct Observation of Stable Internally Ordered Janus Nanoparticles Created by Lipid Self-Assembly.

Tran, Nhiem; Mulet, Xavier; Hawley, Adrian M; Conn, Charlotte E; Zhai, Jiali; Waddington, Lynne J; Drummond, Calum J · Nano Lett · 2015

basic_science · Level V

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Abstract

We present the first observation of Janus nanoparticles consisting of stable, coexisting ordered mesophases in discrete particles created by lipid self-assembly. Cryo-TEM images provided visual identification of the multicompartment Janus nanoparticles and, combined with SAXS data, confirmed the presence of mixed cubic phases and mixed cubic/hexagonal phases within individual nanoparticles. We further investigated computer visualization models to interpret the potential interface between the interconnected coexisting nanostructured domains within a single nanoparticle.