DSigDB: drug signatures database for gene set analysis.
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- Record sourced from PubMed, PMID 25990557.
- Also identified by DOI 10.1093/bioinformatics/btv313 and PMC identifier 4668778.
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Abstract
We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research. DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB. Supplementary data are available at Bioinformatics online. aikchoon.tan@ucdenver.edu.
Medical subject headings
- Computational Biology
- Databases, Pharmaceutical
- Gene Expression Profiling
- Gene Expression Regulation
- Lung Neoplasms
- Protein Kinase Inhibitors
- Software