Human papillomavirus infection and fertility alteration: a systematic review.
systematic_review · Level I
Where this comes from
- Record sourced from PubMed, PMID 25992782.
- Also identified by DOI 10.1371/journal.pone.0126936 and PMC identifier 4436317.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BACKGROUND: HPV is the most prevalent sexually transmitted infection and its effect in cancer induction is well documented. HPV infections are mostly asymptomatic, but it is unclear whether HPV infections can result in alterations of reproductive health. OBJECTIVE: To determine the relationship between human papillomavirus infections and reproductive health in both men and women. METHODS: A systematic literature review was performed in PubMed and ScienceDirect data bases from January 1994 through August 2014. RESULTS: HPV infections are shown to be significantly associated to many adverse effects in the reproductive function. These adverse effects were reported in different levels from cells production to pregnancy and may be related to the infecting genotype. CONCLUSIONS: It appears from this study that HPV detection and genotyping could be of great value in infertility diagnosis at least in idiopathic infertility cases. Like for the risk of carcinogenesis, another classification of HPV regarding the risk of fertility alteration may be considered after deep investigations.
Medical subject headings
- Fertility
- Infertility, Female
- Papillomaviridae
- Papillomavirus Infections