Growth Factor Receptor Fusions Predict Therapeutic Sensitivity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25995339.
- Also identified by DOI 10.1158/1078-0432.CCR-15-0458.
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Abstract
Dysregulated growth factor pathways promote tumor growth in many cancers, but receptor-targeting strategies frequently offer limited benefit despite activation by receptor overexpression or amplification. In contrast, tumors harboring growth factor receptor fusions display exquisite dependence on receptor activity, providing predictive markers for patient response to inform precise oncology treatment.
Medical subject headings
- Antineoplastic Agents
- Brain Neoplasms
- Glioma
- Oncogene Proteins, Fusion
- Pyrazoles
- Quinoxalines