MicroRNA biogenesis pathways in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25998712.
- Also identified by DOI 10.1038/nrc3932 and PMC identifier 4859809.
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Abstract
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
Medical subject headings
- MicroRNAs
- Neoplasms