Deciphering the tubulin code.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26000474.
- Also identified by DOI 10.1016/j.cell.2015.05.004.
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Abstract
Enzymes of the tubulin tyrosine ligase-like (TTLL) family posttranslationally modify and thereby mark microtubules by glutamylation, generating specific recognition sites for microtubule-interacting proteins. Garnham et al. report the first structure of a TTLL protein alone and in complex with microtubules, elucidating their mechanism of action.
Medical subject headings
- Peptide Synthases