Alike but Different: RAF Paralogs and Their Signaling Outputs.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26000477.
- Also identified by DOI 10.1016/j.cell.2015.04.045.
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Abstract
RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.
Medical subject headings
- Carcinogenesis
- MAP Kinase Signaling System
- Proto-Oncogene Proteins c-raf