SnapShot: Intrinsic Structural Disorder.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26000490.
- Also identified by DOI 10.1016/j.cell.2015.05.024.
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Abstract
Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functional state.
Medical subject headings
- Proteins