tmle.npvi: targeted, integrative search of associations between DNA copy number and gene expression, accounting for DNA methylation.
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- Record sourced from PubMed, PMID 26002884.
- Also identified by DOI 10.1093/bioinformatics/btv320.
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Abstract
We describe the implementation of the method introduced by Chambaz et al. in 2012. We also demonstrate its genome-wide application to the integrative search of new regions with strong association between DNA copy number and gene expression accounting for DNA methylation in breast cancers. An open-source R package tmle.npvi is available from CRAN (http://cran.r-project.org/). pierre.neuvial@genopole.cnrs.fr.
Medical subject headings
- Breast Neoplasms
- Computational Biology
- DNA Copy Number Variations
- DNA Methylation
- Gene Expression Regulation, Neoplastic
- Genome, Human
- Software