Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26005812.
- Also identified by DOI 10.1038/nmeth.3410 and PMC identifier 4490062.
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Abstract
We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies' complex attributes and behavioral patterns.
Medical subject headings
- Drosophila melanogaster
- High-Throughput Screening Assays
- Robotics