Simple amides of oleanolic acid as effective penetration enhancers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26010090.
- Also identified by DOI 10.1371/journal.pone.0122857 and PMC identifier 4444294.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transdermal transport is now becoming one of the most convenient and safe pathways for drug delivery. In some cases it is necessary to use skin penetration enhancers in order to allow for the transdermal transport of drugs that are otherwise insufficiently skin-permeable. A series of oleanolic acid amides as potential transdermal penetration enhancers was formed by multistep synthesis and the synthesis of all newly prepared compounds is presented. The synthetized amides of oleanolic acid were tested for their in vitro penetration promoter activity. The above activity was evaluated by means of using the Fürst method. The relationships between the chemical structure of the studied compounds and penetration activity are presented.
Medical subject headings
- Amides
- Oleanolic Acid
- Skin Absorption