The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 26010840.
- Also identified by DOI 10.1371/journal.pone.0127956 and PMC identifier 4444353.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BACKGROUND: We evaluated the diagnostic accuracy of the urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility. METHODS: Between September 2009 and October 2010, male offenders were screened for tuberculosis (symptoms, chest radiograph, two spot sputum specimens for microscopy and culture), and urine tested for LAM. Sensitivity, specificity and predictive values of LAM were calculated using definite and probable tuberculosis combined as our gold standard. FINDINGS: 33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative offenders the sensitivity and specificity of LAM was 7.1% vs. 0% and 98.5% vs. 99.8% respectively. CONCLUSION: Urine LAM ELISA has inadequate sensitivity for TB screening in this population.
Medical subject headings
- Lipopolysaccharides
- Mass Screening
- Tuberculosis, Pulmonary