Urea and protein carbamylation in ESRD: surrogate markers or partners in crime?
Level V
Where this comes from
- Record sourced from PubMed, PMID 26024026.
- Also identified by DOI 10.1038/ki.2015.78 and PMC identifier 4903078.
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Abstract
Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated protein have been shown to be associated with increased risk of death from cardiac causes in patients with end-stage renal disease. The precise mechanism by which carbamylated proteins mediate toxicity in uremia needs further investigation.
Medical subject headings
- Atorvastatin
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Heart Failure
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Kidney Failure, Chronic
- Serum Albumin