Plasmodium falciparum genetic crosses in a humanized mouse model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26030447.
- Also identified by DOI 10.1038/nmeth.3432 and PMC identifier 4547688.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.
Medical subject headings
- Crosses, Genetic
- Plasmodium falciparum