Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26033422.
- Also identified by DOI 10.1002/adma.201501351 and PMC identifier 4862031.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.
Medical subject headings
- Cell Culture Techniques
- Cell Differentiation
- Pluripotent Stem Cells
- Polymers