Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26033838.
- Also identified by DOI 10.1002/adhm.201500075.
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Abstract
Intracellularly degradable, self-assembled amphiphilic biotin-poly(ethylene glycol)-b-poly(curcumin-dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor-targeted accumulation and stimuli-triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual-drug therapy to further enhance in vivo anticancer efficacy.
Medical subject headings
- Curcumin
- Drug Carriers
- Nanoparticles
- Polymers