Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.
Where this comes from
- Record sourced from PubMed, PMID 26039411.
- Also identified by DOI 10.1371/journal.pone.0128814 and PMC identifier 4454596.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are strongly associated with patient survival.
Medical subject headings
- DNA Methylation
- Epigenesis, Genetic
- Neoplasm Proteins
- Pancreatic Neoplasms
- Pancreatitis