Leptin keeps working, even in obesity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26039442.
- Also identified by DOI 10.1016/j.cmet.2015.05.017.
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Abstract
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling. In this issue, Ottaway et al. (2015) use leptin antagonists to reveal persistence (or even elevation) of endogenous leptin signaling and physiologic action in diet-induced obesity.
Medical subject headings
- Diet
- Leptin
- Obesity