Innate immune recognition of mtDNA--an undercover signal?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26039443.
- Also identified by DOI 10.1016/j.cmet.2015.05.019.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In addition to their roles in cellular metabolism and apoptosis, mitochondria function as signaling platforms in the innate immune response. In Nature, West et al. (2015) demonstrate that mitochondrial stress triggers a type I interferon response and confers viral resistance via release of mtDNA and activation of the cGAS-STING pathway.
Medical subject headings
- DNA, Mitochondrial
- Herpesvirus 1, Human
- Immunity, Innate
- Stress, Physiological