The reparative function of cardiomyocytes in the infarcted myocardium.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26039445.
- Also identified by DOI 10.1016/j.cmet.2015.05.015.
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Abstract
Effective repair of the infarcted heart requires spatial containment of the inflammatory reaction within the infarcted area. A recently published study demonstrates that in the pro-inflammatory environment of the infarct border zone, surviving cardiomyocytes restrain inflammation by activating a Reg3β-dependent cascade that recruits reparative macrophages and promotes neutrophil clearance.
Medical subject headings
- Antigens, Neoplasm
- Biomarkers, Tumor
- Lectins, C-Type
- Macrophages
- Myocardial Ischemia
- Myocardium
- Oncostatin M
- Proteins