Click-engineered, bioresponsive, drug-loaded PEG spheres.
basic_science · Level V
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- Record sourced from PubMed, PMID 26042942.
- Also identified by DOI 10.1002/adma.200900421.
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Abstract
A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.