Basophils exhibit antibacterial activity through extracellular trap formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26043360.
- Also identified by DOI 10.1111/all.12662.
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Abstract
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
Medical subject headings
- Bacteria
- Basophils
- Extracellular Traps