Forget the Parents: Epigenetic Reprogramming in Human Germ Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26046435.
- Also identified by DOI 10.1016/j.cell.2015.05.039.
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Abstract
Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the transcriptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptional network and progressive and conserved global erasure of DNA methylation.
Medical subject headings
- Cell Differentiation
- Genomic Imprinting
- Germ Cells
- Proto-Oncogene Proteins c-kit