Tex10: A New Player in the Core Pluripotency Circuitry.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26046753.
- Also identified by DOI 10.1016/j.stem.2015.04.019.
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Abstract
Revealing how the core pluripotency circuitry is orchestrated to maintain the ground state of embryonic stem cells (ESCs) is fundamental for understanding self-renewal and early lineage specifications. In this issue of Cell Stem Cell, Ding et al. (2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.
Medical subject headings
- Cellular Reprogramming
- Enhancer Elements, Genetic
- Epigenesis, Genetic
- Nuclear Proteins
- Pluripotent Stem Cells