Can Metabolic Mechanisms of Stem Cell Maintenance Explain Aging and the Immortal Germline?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26046756.
- Also identified by DOI 10.1016/j.stem.2015.04.021 and PMC identifier 5797848.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mechanisms underlying the aging process are not understood. Even tissues endowed with somatic stem cells age while the germline appears immortal. I propose that this paradox may be explained by the pervasive use of glycolysis by somatic stem cells as opposed to the predominance of mitochondrial respiration in gametes.
Medical subject headings
- Aging
- Germ Cells
- Stem Cells