Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26046760.
- Also identified by DOI 10.1016/j.stem.2015.05.002 and PMC identifier 4509784.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here we discuss possible explanations for age-associated increases in the initiation and/or progression of mutant stem/progenitor clones and highlight the roles of stem cell quiescence, replication-associated DNA damage, telomere shortening, epigenetic alterations, and metabolic challenges as determinants of stem cell mutations and clonal dominance in aging.
Medical subject headings
- Aging
- Mutation
- Neoplasms
- Stem Cells