The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26047514.
- Also identified by DOI 10.1371/journal.pone.0128696 and PMC identifier 4457841.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a weighted network, constructed using chemical-chemical interaction information, to identify new chemicals related to two types of lung cancer: non-small lung cancer and small-cell lung cancer. Then, a randomization test as well as chemical-chemical interaction and chemical structure information were utilized to make further selections. A final analysis of these new chemicals in the context of the current literature indicates that several chemicals are strongly linked to lung cancer.
Medical subject headings
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Drug Discovery
- Lung
- Lung Neoplasms
- Small Cell Lung Carcinoma