Design of a micellized α-cyclodextrin based supramolecular hydrogel system.
basic_science · Level V
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- Record sourced from PubMed, PMID 26053135.
- Also identified by DOI 10.1039/c5sm00665a.
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Abstract
In recent years supramolecular structures built from macrocyclic compounds have attracted tremendous interest due to the unique properties derived from dynamic self-assembly. Our study proposes a two-step mechanism to form a supramolecular hydrogel system: (1) the formation of micelles, and (2) micelle association with α-cyclodextrin (α-CD) due to threading of PEGMA in the α-CD cavity, forming inclusion complexes. Using this mechanism, a supramolecular hydrogel made from a tri-component copolymer PLLA/DMAEMA/PEGMA and α-CD was fabricated for the first time and characterized in terms of its structural, morphological, and rheological properties.