BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.
basic_science · Level V
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- Record sourced from PubMed, PMID 26059717.
- Also identified by DOI 10.1093/bioinformatics/btv351.
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Abstract
Genomics has revolutionized biological research, but quality assessment of the resulting assembled sequences is complicated and remains mostly limited to technical measures like N50. We propose a measure for quantitative assessment of genome assembly and annotation completeness based on evolutionarily informed expectations of gene content. We implemented the assessment procedure in open-source software, with sets of Benchmarking Universal Single-Copy Orthologs, named BUSCO. Software implemented in Python and datasets available for download from http://busco.ezlab.org. evgeny.zdobnov@unige.ch Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology
- Gene Dosage
- Genome
- Genomics
- Molecular Sequence Annotation
- Software