Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26059746.
- Also identified by DOI 10.1002/adhm.201500258 and PMC identifier 4545642.
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Abstract
Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture.
Medical subject headings
- High-Throughput Screening Assays
- Hyaluronic Acid
- Hydrogel, Polyethylene Glycol Dimethacrylate