Tracking single-particle rotation during macrophage uptake.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26059797.
- Also identified by DOI 10.1039/c5sm00893j and PMC identifier 4657870.
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Abstract
We investigated the rotational dynamics of single microparticles during their internalization by macrophage cells. The microparticles used were triblock patchy particles that display two fluorescent patches on their two poles. The optical anisotropy made it possible to directly visualize and quantify the orientation and rotation of the particles. We show that particles exhibit a mixture of fast and slow rotation as they are uptaken by macrophages and transiently undergo directional rotation during their entry into the cell. The size of the particles and the surface presentation of ligands exerted a negligible influence on this heterogeneity of particle rotation.
Medical subject headings
- Macrophages
- Microspheres
- Rotation