Insights into the origin of the nuclear localization signals in conserved ribosomal proteins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26066547.
- Also identified by DOI 10.1038/ncomms8382 and PMC identifier 4490412.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
Medical subject headings
- Cell Nucleus
- Escherichia coli Proteins
- Nuclear Localization Signals
- RNA, Ribosomal
- Ribosomal Proteins
- Saccharomyces cerevisiae Proteins