A Newly Emerged Swine-Origin Influenza A(H3N2) Variant Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26068782.
- Also identified by DOI 10.1093/infdis/jiv330 and PMC identifier 5240150.
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Abstract
We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
Medical subject headings
- Inflammasomes
- Influenza A Virus, H1N1 Subtype
- Influenza A Virus, H3N2 Subtype
- Leukocytes, Mononuclear