Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26069963.
- Also identified by DOI 10.1371/journal.pone.0129817 and PMC identifier 4466397.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.
Medical subject headings
- Cyclohexanones
- DNA
- Intercalating Agents