Multiple independent autonomous hydraulic oscillators driven by a common gravity head.
basic_science · Level V
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- Record sourced from PubMed, PMID 26073884.
- Also identified by DOI 10.1038/ncomms8301 and PMC identifier 4470298.
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Abstract
Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s-2 h) and flow rates (0.10-63 μl min(-1)) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.
Medical subject headings
- Endothelial Cells
- Gravitation
- Microfluidics
- Pulsatile Flow