Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26076445.
- Also identified by DOI 10.1371/journal.pone.0130389 and PMC identifier 4468131.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of the cinnamon-derived molecule IND02 on the adhesion of leukocytes to host cells. The anti-inflammatory ability of IND02, a pentameric procyanidin type A polyphenol polymer isolated from cinnamon alcohol extract, was examined. Pretreatment with IND02 significantly reduced the attachment of THP-1 cells or neutrophils to TNF-α-activated HUVECs or E-selectin/ICAM-1, respectively. IND02 also reduced the binding of E-, L- and P-selectins with sialosides. Furthermore, IND02 could agglutinate human red blood cells (RBC), and the agglutination could be disrupted by sialylated glycoprotein. Our findings demonstrate that IND02, a cinnamon-derived compound, can interact with sialosides and block the binding of selectins and leukocytes with sialic acids.
Medical subject headings
- Cell Adhesion
- Cinnamomum zeylanicum
- Erythrocyte Aggregation
- Human Umbilical Vein Endothelial Cells
- Neutrophils
- Proanthocyanidins