Trypanosoma brucei gambiense Spliced Leader RNA Is a More Specific Marker for Cure of Human African Trypanosomiasis Than T. b. gambiense DNA.
other · Level V
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- Record sourced from PubMed, PMID 26080371.
- Also identified by DOI 10.1093/infdis/jiv337.
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Abstract
To assess the efficacy of treatment for human African trypanosomiasis, accurate tests that can discriminate relapse from cure are needed. We report the first data that the spliced leader (SL) RNA is a more specific marker for cure of human African trypanosomiasis than parasite DNA. In blood samples obtained from 61 patients in whom human African trypanosomiasis was cured, SL RNA detection had specificities of 98.4%-100%, while DNA detection had a specificity of only 77%. Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure.
Medical subject headings
- DNA, Protozoan
- Drug Monitoring
- RNA, Spliced Leader
- Trypanosoma brucei gambiense
- Trypanosomiasis, African