Nox4 Is Dispensable for Exercise Induced Muscle Fibre Switch.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26083642.
- Also identified by DOI 10.1371/journal.pone.0130769 and PMC identifier 4471227.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
INTRODUCTION: By producing H2O2, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal. Here we hypothesized that Nox4 contributes to exercise-induced adaptation such as changes in muscle metabolism or muscle fibre specification and studied this in wildtype and Nox4-/- mice. RESULTS: Exercise, as induced by voluntary running in a running wheel or forced running on a treadmill induced a switch from fast twitch to intermediate fibres. However the induced muscle fibre switch was similar between Nox4-/- and wildtype mice. The same held true for exercise-induced expression of PGC1α or AMPK activation. Both are increased in response to exercise, but with no difference was observed between wildtype and Nox4-/- mice. CONCLUSION: Thus, exercise-induced muscle fibre switch is Nox4-independent.
Medical subject headings
- Adaptation, Physiological
- Muscle Fibers, Fast-Twitch
- Muscle Fibers, Slow-Twitch
- NADPH Oxidases
- Physical Conditioning, Animal