Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.

Chattaraj, Rajarshi; Mohan, Praveena; Besmer, Jeremy D; Goodwin, Andrew P · Adv Healthc Mater · 2015

basic_science · Level V

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Abstract

Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin is sensed down to 1 × 10(-13) m, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.

Medical subject headings