Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26088467.
- Also identified by DOI 10.1002/adhm.201500334 and PMC identifier 4825875.
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Abstract
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong and -ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization.
Medical subject headings
- Biocompatible Materials
- Delayed-Action Preparations
- Hydrogels
- Trehalose